1. Which of the following is a phase II drug metabolizing reaction ?
(a) Acetylation
(b) Deamination
(c) Oxidation
(d) Reduction

2. A good example of chemical antagonism
(a) Heparin & Protamine
(b) Protamine & Zinc
(c) Heparin & Prothrombin
(d) All the above

3. The rate of drug absorption is greatest in:
(a) The small intestine
(b) The large intestine
(c) The stomach
(d) All of above

4. Acetylcholine and atropine action on the muscarinic receptors is a classical example of
(a) Competitive antagonism
(b) Non-competitive antagonism
(c) Physiological antagonism
(d) Chemical antagonism

5. Which type of drugs penetrate CNS better
(a) Lipid soluble
(b) Weak acids
(c) Weak bases
(d) All equally

6. Phocomelia is a known teratogenic effect of
(a) Anticancer drugs
(b) Antiviral drugs
(c) Antiepileptic drugs
(d) Thalidomide

7. A ‘toxic effect’ differs from a ‘side effect’ in that
(a) It is not a pharmacological effect of the drug
(b) It is a more intense pharmacological effect that occurs at high dose or after prolonged medication
(c) It must involve drug induced cellular injury
(d) It involves host defence mechanisms

8. Which tissue has the greatest capacity to biotransform drugs?
(a) Brain
(b) Kidney
(c) Liver
(d) Lung

9. Which antiemetic selectively blocks levodopa induced vomiting without blocking its antiparkinsonian
action ?
(a) Metoclopramide
(b) Cisapride
(c) Domperidone
(d) Ondansetron

10. Which prokinetic drug(s) produce(s) extrapyramidal side effects ?
(a) Metoclopramide
(b) Cisapride
(c) Domperidone
(d) All of these

11. The most potent drug for prevention of motion sickness is
(a) Dimenhydrinate
(b) Tripelenamine
(c) Scopolamine
(d) Hydroxygene

12. Megaloblastic anemia is caused by deficiency of
(a) Iron
(b) Vitamin B12
(c) Vitamin C
(d) All of the above

13. Which vitamin deficiency in Antibiotic using patient?
(a) Thiamin
(b) Vitamin k
(c) Vitamin B12
(d) Vitamin E

14. cAMP is an example of
(a) Neurohormone
(b) Neuromodulator
(c) Neuromediator
(d) Neurotransmitter

15. Opioid angalgesics provide symptomatic relief of
(a) Pain
(b) Cough
(c) Diarrhea
(d) All of the above

16. Which of the benzodiazepines is used only as a sedative and hypnotic
(a) Chlordiazepoxide
(b) Clorazepam
(c) Diazepam
(d) Flurazepam

17. Which of the following secretions is not stimulated by acetylcholine ?
(a) Tear
(b) Bile
(c) Sweat
(d) Pancreatic juice

18. The maximum daily dose of Alprazolam is
(a) Anxiolytic
(b) Sedative
(c) Antidepressant
(d) All of the above

19. The most common adverse reaction to insulin is
(a) Hypoglycaemia
(b) Lipodystrophy
(c) Urticaria
(d) Angioedema

20. The antidiabetic agent most likely to cause lactic acidosis is
(a) Chlorpropamide
(b) Phenformin
(c) Glipizide
(d) Metformin

21. Preferred route of insulin is
(a) Oral
(b) Subcutaneous
(c) Sublingual
(d) Enteric coated tabs

22. MAO inhibitors in general raise the brain level of
(a) Dopamine
(b) Serotonin
(c) Nor adrenaline
(d) All of the above

23. The local anaesthetic of choice during labor is
(a) Procaine
(b) Bupivacaine
(c) Cocaine
(d) Lignocaine

24. Ipratropium bromide is principally effective in
(a) Asthma
(b) Bronchitis
(c) COPD
(d) All of the above

25. Synthesis of norepinephrine occurs from
(a) Tyramine
(b) Tyrptophan
(c) Tyrosine
(d) Tetracaine

26. Peripheral conversion of levodopa to dopamine is facilitated by:
(a) Thiamine
(b) Ribo§avin
(c) Pyridoxine
(d) Cyanocobalamin

27. Potassium sparing diuretics should not be coadministered with
(a) Furosemide
(b) Hydrochlorothiazide
(c) Captopril
(d) Verapamil

28. Route of heparin administration is
(a) Oral
(b) Subcutaneous
(c) Intramuscular
(d) Sublingual

29. The following laxative lowers blood ammonia level in hepatic encephalopathy.
(a) Bisacodyl
(b) Liquid paraffin
(c) Lactulose
(d) Magnesium sulfate

30. Antacids should not be prescribed concurrently with
(a) Ranitidine
(b) Pirenzipine
(c) Sucralfate
(d) Omeprazole

31. A woman in the 28th week of pregnancy has been found to have pregnancy induced hypertension with a blood pressure reading of 150/95 mm Hg. Select the most appropriate antihypertensive drug for her:
(a) Furosemide
(b) Methyldopa
(c) Propranolol
(d) Captopril

32. The antiparkinsonian drug which acts by inhibiting the degradation of dopamine in the brain is
(a) Carbidopa
(b) Amantadine
(c) Selegiline
(d) Bromocriptine

33. Earliest sign of aspirin toxicity is
(a) Tinnitus
(b) Metabolic acidosis
(c) Reye syndrome
(d) Respiratory depression

34. The corticosteroid with a longer duration of action is
(a) Cortisone
(b) Prednisone
(c) Betamethasone
(d) Fludrocortisone

35. For a patient of peptic ulcer, the safest nonopioid analgesic is
(a) Ketorolac
(b) Diclofenac sodium
(c) Paracetamol
(d) Ibuprofen

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